Keratinocytes transcriptional regulation of gene expression.docVIP

 PAGE \* MERGEFORMAT 18 Keratinocytes transcriptional regulation of gene expression Abstract: keratinocyte proliferation and differentiation is a subject to fine-tune the process, and accompanied by a series of morphological and biochemical changes, ultimately the formation of skin cells, which necessarily involves a number of structural gene activation and inactivation at the same time, that gene the regulation of expression, while the level of transcription regulation is particularly important. Has been found that many transcription factors such as AP1, AP2, Sp1, POU domain and the C / EBP and other adjustable gene expression in keratinocytes. Epidermis is the body’s first protective barrier, consisting mainly of cells and keratinocytes, in order to complete its barrier function, keratinocytes must be complex and subject to tight regulation of the differentiation process, the final shape, including basal layer, acanthosis, particle layer, transparent layer and stratum corneum of the complex layer structure [1]. Epidermal layers of cells in the morphological and biochemical differences in levels of both, such as the spine layer and granular layer of the expressed protein was absent in the basal layer, which mainly related to keratinocyte differentiation genes within a specific time during the ‘open’ (activation) or ‘off’ (inactivated), and therefore the past 10 years keratinocytes keratinocyte gene regulation has become one of the hot cell biology research [2]. Gene regulation can be divided into several levels: transcription, translation levels and post-translational level, the most common way is the regulation of transcription regulation. Has been found that AP1, AP2, NFκ B, C / EBP, ets, Sp1 and the POU-domain transcription factors, such as the regulation of epidermal proteins, thus regulating membrane protein encoded sets (involucrin, iNV), transglutaminase (transglutaminase , TG), SPRR2A, pocket A protein (loricrin), proteins such as keratin and BPAG1