Linesinine on focal cerebral ischemia in C.docVIP

 PAGE \* MERGEFORMAT 5 Linesinine on focal cerebral ischemia in C Author: Yu Wan Gui Tran Dinh Xuan Zhang Heng-wen Xie Ping, Zhang Yin-cheong, Zhang Tao-ming, LIU Lian Deng Deming [Keywords:] Liensinine;,, cerebral ischemia;,, C Abstract: Objective To observe the linesinine on focal cerebral ischemia CFos protein expression and to explore the protective mechanism. Methods Preparation of rat suture model of focal cerebral ischemia by immunohistochemical detection of brain ischemia and 24 h CFos protein expression, as well as by liensinine (3 mg / kg) treatment on the protein expression. The results of cerebral ischemia 24 h CFos protein expression was significantly increased, Liensinine significantly inhibited protein expression after cerebral ischemia CFos. Conclusion liensinine neural protective mechanisms may be related to inhibition CFos protein expression. Keywords: Liensinine; cerebral ischemia; CFos protein Abstract: ObjectiveTo observe the effect of liensinine on CFos protein expression in Rats with focal cerebral ischemia and investigate its protective mechanism. MethodsThe model of focal cerebral ischemia in rats was made by suture-occluded method, the expression of CFOS protein and the effect of Liensinine (3mg/kg) applied prior ischemia on the expression were detected by immunohistochemical method after cerebral ischemia 24 h. ResultsThe expression of CFOS protein significantly increased after 24 h ischemia and Liensinine significantly inhibited the expression of CFos.ConclusionThe protective mechanism of Liensinine is probably related to the inhibition of CFOS gene expression. Keywords:: Liensinine; Cerebral ischemia; CFos Protein CFos protein is apoptosis-related genes C-Fos expression product is sensitive to ischemia, can be used as study drug intervention after cerebral ischemia in the target [1]. Liensinine extracted from traditional Chinese medicine lotus hearts isolated from pairs of benzyl-isoquinoline compounds, with blood pressure,