371例重症病房感染常见病原菌及其耐药性分析.pdfVIP

78 现代医院 20 日军 6 月第 13 卷第 6 期专业执点精 Modern Hospital Jun 2013 Vol13 No 6 371 例重症病房感染常见病原菌及真耐药性分析 黄钟雄詹鹏飞 肖俊锐 ANALYSIS OF THE COMMON PATHOGENS AND THEIR DRUG RESISTANCE OF 371 CASES OF INFECTION IN ICU HUANG Zhongxiong , ZHAN Pengfei , XIAO }unrui {摘 要] 目的 了解我院重症病房常见致病菌感染情况及其耐药性，为病原学调查及临床诊治提供 依据。方法 采用回顾性调查的方法，对 2010 年 1 月 -2011 年 12 月汕头市中医医院重症病房细菌感染病例 进行分析。结果 两年间重症病房检出致病菌为 371 株;两年间重症病房细菌感染率 (33.8% )高于同期医院 感染率 (8.2%) (p 0. 05) 。两年致病菌检出率差异显著 (p 0. 05) 。所分离出细菌中以 G- 杆菌 (69.0% )居 多，其次为 G+ 球菌 (24.5%) ，其中铜绿假单胞茵和金黄色葡萄球菌为最主要致病菌， G- 杆菌对亚膝培南有 较高敏感(耐药率 3 1. 3% -34.6%) ，产 ESBLs大肠埃希菌的发生率较高 (35.9%) ，耐甲氧西林金黄色葡萄球 菌 (MRSA) 发生率为 89.2% 。未发现耐万古霉素的 G+ 球菌。结论 重症病房感染致病菌多为多重耐药菌 株，应对常见病原菌耐药动态加强系统监测，为指导临床科学使用抗生素，减少院内感染提供参考依据。 【关键词】 重症病房细菌感染病原菌耐药性 [ Abstract 1 0均创刊 To investigate 出 e common pathogens and their dr吨 resistance in ICU as an etiologi? cal investigation and provide the basis for clinical diagnosis and treatment. Me伽ωs A retrospective investigation method was used to analyze the bacterial infection cases in ICU from 2010 to 201 1. Results There were 371 strains of pathogens in ICU during these two years , where bacterial infection rate was 33.8% higher than 由at in hospital (8.2%) in the same period (p OH05). 叽lere was dramatic si伊ificant difIerence in pathogen detection rates be? tween 2010 and 2011(p 0. 05). 四e majority of pathogens were Gram negative bacteria , followed by Gram positive bacteria. Among those the Pseudomonas Aeruginosa and Staphylococcus aureus were the main bacteria. Gram nega? tive bacteria had a high sensitivity to imipenem (resist四ce rate between 31. 3% and 34.6% ). Incidence of ESBLs in E. coli was high (35.9%) a