Markers of myocardial damage and clinical application of laboratory diagnosis and evaluation of research progress.doc

 PAGE \* MERGEFORMAT 12 Markers of myocardial damage and clinical application of laboratory diagnosis and evaluation of research progress [Keywords:] markers of myocardial damage clinical application of laboratory diagnosis Acute myocardial infarction (AMI) is a common clinical acute cardiovascular disease, serious harm to people’s lives and health, the diagnosis of AMI, the medical profession has always been of concern. AMI patients, about 1 / 4 no typical clinical symptoms of early, about 50.0 % no specific ECG changes, so cardiac laboratory markers in the diagnosis of AMI have a very important position. but disease progression in patients with acute AMI and laboratory tests for a long time, and no specific target has been plagued us the problem, after decades of study, cardiac markers in the portfolio of laboratory testing, experimental methods, have detected a major breakthrough time, the paper of their research and clinical applications were reviewed. A serum enzyme markers of early studies (AST, CK-MB, CK) Biochemical markers of AMI early focus on the serum enzyme markers. AMI marker of serum enzymes began in 1954, Karman and other sensitive use of quantitative paper chromatography, AMI patients measured aspartate aminotransferase (AST ) activity, AMI patients with elevated serum AST and became the first AMI, serum enzyme markers. serum AST, there are two isozymes controlled by different genes, respectively, in the cytoplasm (c-AST) and mitochondrial (m-AST) inside. AST clinically significant increase; was developed to simultaneously detect creatine kinase (CK), creatine kinase (CK-MB); AST, CK, CK-MB as the diagnosis of AMI, the traditional serum markers, but its specificity is not high, some diseases can lead to false positive, such as liver disease, heart disease, myocarditis, skeletal muscle trauma, pulmonary embolism, shock, and diabetes can affect its specificity. 2 damage and myocardial necrosis markers Previous biochemical diagno