Matrix metalloproteinase and tissue inhibitor of the role of endometriosis Progress.doc

 PAGE \* MERGEFORMAT 13 Matrix metalloproteinase and tissue inhibitor of the role of endometriosis Progress [Keywords:] matrix metalloproteinases, tissue inhibitor of metalloproteinases, endometriosis, research progress Endometriosis (Endometrosis, EMs) is the endometrial tissue (glands and stroma in the uterine endometrium and myometrium cavity covered areas other than the emergence, growth, invasion, repeated bleeding, the endometrial cells characterized by ectopic growth. mainly affects women of reproductive age, is one of the common gynecological diseases, the incidence was significantly higher in recent years, accounting for 10% of the population of women to 15% in women of reproductive age in the incidence rate as high as 30 % [1]. EMs as benign lesions, but some of its biological behavior is similar to the malignant behavior, especially those with tissue invasion, the ability of distant planted. dysmenorrhea, and infertility can cause serious physical and mental health problems a large number of women . EMs has been the intractable disease gynecology, obstetrics and gynecology at home and abroad scholars have been efforts to explore its pathogenesis, but so far have been inconclusive. Studies have shown that endometrial fragments (glandular epithelium and stroma) must pass the adhesion, invasion and angiogenesis, can survive, grow, and cause lesions and symptoms. Currently, many studies also from adhesion, invasion and angiogenesis-related factors to proceed, trying to find the pathogenesis of EMs. One of the major relevant factors including the integrin family related factor, matrix metalloproteinase (metrix metalloproteinase, MMPs) and tissue inhibitor of metalloproteinase (tissueinhibitors of metalloproteinase, TIMPs), vascular endothelial growth factor (VEGF) and its receptor (KDR), and these are also the pathogenesis of EMs hot This article on MMP and TIMP in the EMs in the research reviewed in this paper. 1 MMPs and TIMPs MMPs are a g