Matrix metalloproteinases and their inhibitors in osteoarthritis.doc

 PAGE \* MERGEFORMAT 15 Matrix metalloproteinases and their inhibitors in osteoarthritis [Keywords:] osteoarthritis; matrix metalloproteinase; matrix metalloproteinase inhibitor Osteoarthritis (osteoarthritis, OA) is a common degenerative joint disease, articular cartilage damage, osteophytes, articular surface, synovial hyperplasia, synovitis and joint space narrowing. Pathologic process to articular cartilage damage is characterized by matrix degradation, its causes is not clear. Recent studies show that, OA articular cartilage matrix metalloproteinases (matrix metalloproteinases, MMPs) synthesis, matrix metalloproteinase-specific inhibitor (Tissue Inhibitor of Metalloproteinases, TIMPs ) synthesis reduced, resulting in cartilage extracellular matrix (extracellular matrix, ECM) synthesis and degradation of imbalance led to an important reason for the degeneration of cartilage [1]. In this paper, MMPs and TIMPs with OA an overview of related research. Classification and plasminogen activator 1MMPs MMPs are a class of widely distributed in the connective tissue structure similar to the protease family, by fibroblasts, epithelial cells, inflammatory cells, endothelial cells, ECM degradation is the most important proteolytic system, is considered the body’s physiological and pathological damage reconstruction One of the main fundamentals. MMPs can degrade almost all due to the extracellular matrix of cartilage in OA has been considered to play an important role in the pathogenesis. according to their protein structure and substrate specificity can be divided into five subtypes: ( 1) collagenase (MMP 1, 8, 13). (2) gelatinase (MMP 2, 9). (3) interstitial matrilysin (MMP 3, 10, 11). (4) model MT MMPs (MMP 14 , 15, 16, 17, 24, 25). (5) Other sub-groups (MMP 7, 12, 20, 23). MMPs can directly cut off the cartilage type II collagen and proteoglycans, the fibrous structure of cartilage arch destruction, damage, cartilage loses its elasticity, the collagen fi