Mechanisms of diabetic vascular disease.docVIP

 PAGE \* MERGEFORMAT 14 Mechanisms of diabetic vascular disease [Abstract] diabetes, diabetic vascular disease is one of the main disability in death, serious impact on quality of life of diabetic patients. Its pathogenesis has not yet fully understood, the current major and oxidative stress that increased polyol pathway activity, nonenzymatic protein glycosylation, protein kinase C pathway activation, endothelial cell injury and so on. [Keywords:], oxidative stress, polyol pathway, non-enzymatic glycation of PKC, endothelial cell injury In recent years, diabetes has become the cancer, cardiovascular disease after the third serious threat to human health from chronic diseases. Diabetic vascular disease is a major complication of diabetes and its macrovascular nature of atherosclerosis (atherosclerosis AS), the main involving the aorta, coronary and other large vessels, and diabetes-specific microvascular disease is a chronic vascular complications of diabetes, mainly as the retina, kidneys and other microvascular disease. Mechanism and prevention of diabetic vascular disease research is research hotspot in recent years. A mechanism for diabetic vascular disease 1.1 Enhanced oxidative stress Oxidative stress is not only the start of factors of diabetic vascular complications, and is closely related with the development of diabetes. Diabetic patients, excessive formation of glucose metabolism of pyruvate by the glycolytic pathway, which provides too much by the citric acid cycle supply of hydrogen donor (NADH and FADH2) to the mitochondrial respiratory chain, so that the reactive oxygen species (ROS), especially the O-2 generation increased. Brownlee [1] proposed that high blood sugar lead to endothelial cell mitochondria generate superoxide anion (O- 2) The increase in diabetic vascular disease is a key factor in the pathogenesis. O-2 generation can cause an increase in the activation of polyol pathway, advanced glycation end products (AGEs) fo