Mechanisms of bile duct disease.docVIP

 PAGE \* MERGEFORMAT 16 Mechanisms of bile duct disease Of: Zouqing Wei, Po Yan, Pu Min, MU East, Bo [Keywords:] bile duct disease; pathogenesis; Research In recent years, with the bile duct disease (Cholangiopathies) [1] the increase in incidence, more and more attention and exploration of domestic and foreign scholars. As a common clinical refractory disease, the pathogenesis is unclear, clinicians can only give limited or symptomatic treatment. Because of this, the pathogenesis of the clinical diagnosis of bile duct disease has important practical significance. A bile duct disease (Cholangiopathies) Overview The role of bile duct disease is a tree in the intrahepatic bile ducts to bile duct epithelial cells (Biliary Epithe-lium Cells, BEC) as the main attack targets a class of diseases collectively known, is one of the clinical common diseases. Its essence is the biliary tree subjected to abnormal repair after injury results in this process, focal or diffuse fibrosis of the biliary tree is the key step is biliary tree injury, expansion, stenosis and pathological basis of stone formation. In addition to genetic etiology factors, but also with the bile duct system, immunity, infection, ischemia, drug toxicity, iatrogenic bile duct injury [2] and other factors. common genetic diseases such as liver bile duct cyst, causes most of the Department of intrahepatic bile duct development disorder due, not repeat them here. the common bile duct non-hereditary diseases, including primary sclerosing cholangitis, primary biliary cirrhosis, diffuse bile duct stones, bile duct after liver transplantation ischemic lesions [3] autoimmune biliary disease [4] and other drug-induced cholangitis. pathogenesis is not clear at present, the lack of a particularly effective treatment, most patients eventually had to accept the bile duct of liver transplantation. According to statistics, in liver transplant recipients , children up to 80% of the bile duct disease, the p