Medicine intervention study the molecular mechanism of liver fibrosis Overview.doc

 PAGE \* MERGEFORMAT 18 Medicine intervention study the molecular mechanism of liver fibrosis Overview [Keywords:] traditional Chinese medicine Keywords: Chinese medicine; liver fibrosis; molecular mechanism of Liver fibrosis is a reversible lesion, and timely intervention can reduce the duration of hepatic fibrosis in cirrhosis of the liver and its deadly complications. Chinese medicine to prevent liver fibrosis research in our country has achieved satisfactory results in recent years, Chinese medicine for prevention and treatment of liver fibrosis in quite a number of studies have reported [1 ~ 5], many of them deep into the molecular level study of the mechanism of [6,7 ], through the traditional Chinese medicines acting on the liver fibrosis in one or more of the disease areas to achieve the purpose of inhibiting hepatic fibrosis. A clear free radicals, removing the incentive for the formation of hepatic fibrosis Liver by the drugs, toxins, ischemia - reperfusion injury, when stimulated, can produce free radicals, when the liver cells exposed to excessive free radicals, the occurrence of oxidative stress, oxidative stress can cause liver cell injury in a variety of ways to . A variety of anti-oxidant herbs can be by raising a variety of free radical scavenging activity of free radicals, blocking hepatic fibrosis. HU Yi-Yang, and others [8] study of Chinese herbal compound on hepatic fibrosis ‘Fuzheng Huayu Capsule’, found that the parties significantly inhibit the proliferation of collagen fibers in the liver, inhibit liver tissue Hyp increased at the same time, their liver to maintain normal levels of SOD activity, while the MDA content in was significantly lower than the model group; liver tissue MDA content between the Hyp content in a very significant correlation. In the DMN-induced rat liver fibrosis model experiments, also observed similar results [9]. Related to a number of studies have reported anti-liver fibrosis compound, such as detoxificati