Medicine Shuganshuru Particles on the chronic toxicity of rabbits.doc

 PAGE \* MERGEFORMAT 10 Medicine Shuganshuru Particles on the chronic toxicity of rabbits [Keywords:] Shuganshuru particle;, and chronic toxicity;,, experimental rabbits;,, morphology Abstract: Objective To observe the effects of Shuganshuru particles (SGSR) in experimental rabbits with chronic toxicological effects of the morphological changes of organs and tissues most. Experimental Methods 12 female rabbits were randomly divided into four groups, namely, normal and high, medium and low dose group, a period of 6 months with chronic toxicological experiment. Of which three dose groups, respectively, 12.6 and 3 ml of drug (the equivalent of Pharmacognosy 240,120 and 60 g) were mixed with the standard pellets are fed directly after high, medium and low-dose group rabbits, control group daily such as volume of saline given to observe the experimental group and control group of indicators of chronic toxicity. The results of experimental rabbits SGSR growth, weight gain, blood biochemistry, as well as the histological structure of important organs had no adverse effects. Conclusion SGSR experimental rabbits had no significant chronic toxicity can be clinically applied. Keywords:: Shuganshuru particle; chronic toxicity; experimental rabbit; morphology The Chronic Toxicity Study of Shugan Shuru Granule on Experimental Rabbits Abstract: ObjectiveTo observe the chronic toxicity and the morphologic changes of organs of Shugan Shuru Granule (SGSR) on experimental rabbits in vivo. MethodsTwelve female rabbits were divided into experiment groups and control group. Experiment group was divided into high, middle and low drug groups which were fed with 240,120 and 60 g of SGSR mixed with standard granule feedstuff respectively for half a year, while the control group was fed with normal saline mixed with standard granule feedstuff. The indexes of toxicity were observed in four groups respectively. ResultsThe growth, weight, serum biochemical indexes and histological stru