Methylenetetrahydrofolate reductase gene polymorphism and lung cancer susceptibility.doc

 PAGE \* MERGEFORMAT 20 Methylenetetrahydrofolate reductase gene polymorphism and lung cancer susceptibility Author: Zou Qingfeng, Sheng-Qiang Chen, Lei Ma, Zhi-Biao Li, Li Weidong, Chen Sheng, Jinchuan, Wu Di 【Abstract】 Objective To study the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and lung cancer susceptibility. Methods PCR  RFLP detected by MTHFR genotype in patients with lung cancer in Guangdong Province and normal population distribution. Results of lung cancer group and control group in the distribution of MTHFR genotypes were significantly different (P = 0.030), between men and women of both sexes, non-small cell lung cancer and between small-cell lung cancer, non-small cell lung cancer in various pathological types of between the various clinical stages of lung cancer cases between the MTHFR C677T polymorphism in no significant difference. Conclusion MTHFR gene C677T mutation in lung cancer cases in the normal population distribution and the distribution of significant differences. Keywords: methylenetetrahydrofolate reductase; gene polymorphism; lung cancer Polymorphisms of 5,10  Methylenetetrahydrofolate Reductase and Risk of Lung Cancer in Guangdong Population Keywords:: Lung cancer; N5, 10  methylenetetrahydrofolate reductase; Gene Polymorphism; Lung Cancer Has been a large number of studies have shown that in tumor pathogenesis, genetic factors play an important role. In addition to being extensively studied oncogenes, tumor suppressor genes, the metabolic enzyme gene polymorphism is also a research direction. Methylenetetrahydrofolate reductase, folic acid metabolic pathway is a key enzyme, its gene mutations in a variety of types, the most common type of mutation C677T point mutation, that is, 677 nucleotide C → T (C ammonia acid → Val) point mutation. To date, studies have shown that MTHFR C677T gene polymorphism and colorectal cancer, stomach cancer, esophageal cancer, the incidenc