Methylcobalamin Tablets Optimization.doc

 PAGE \* MERGEFORMAT 10 Methylcobalamin Tablets Optimization Keywords: Methylcobalamin tablets; prescription; orthogonal set test meter; dissolution 【Abstract】 Objective To screen methylcobalamin tablets composed of the best prescription. Ways to accessories in microcrystalline cellulose (MCC), sodium dodecyl sulfate (SDS-Na), sodium carboxymethyl starch (CMS-Na), powder silica gel (SiliciiDoxydum) for evaluation of factors, each taking three one level, with the L9 (34) orthogonal table to be tested in order to methylcobalamin tablets dissolution study as the main indicators in order to piece weight difference as a reference indicator to carry out orthogonal test [1]. Influence the results of Accessories methylcobalamin tablets dissolution rate of the main factors that sodium lauryl sulfate, the best prescription composed of microcrystalline cellulose (PH101) 35g, sodium dodecyl sulfate 4.0g, sodium carboxymethyl starch 1.5 g, silica gel powder 1.5g. Conclusions obtained in the formulation and preparation of methylcobalamin tablets dissolution rate is higher and stable product quality, preparation is simple and feasible, suitable for industrial mass production. Keywords: methylcobalamin tablets; prescription; orthogonal set test meter; dissolution Study on formulation and preparation technique of mecobalamin tablets 【Abstract】 Objective To select the optimum formulation technique of mecobalamin tablets. Methods The L9 (34) orthogonal table and four factors (dissolution as main factor, weight difference as reference factor) were used to select the best formulation by taking MCC (HP101) , SDS-Na, CMS-Na and silicii doxydum as the four factors, and three levels were adopted for each factors. Results The experimental resultes indicated SDS-Na was the chief factor of influencing dissolution of macobalamin tablets. The optimum formulation was composed of MCC (HP101) 35g, SDS-Na 4.0g, CMS-Na 1.5g and silicii doxydum 1.5g. Conclusion The