Mice Lappaconitine hydrobromide oral pharmacokinetic study of.doc

 PAGE \* MERGEFORMAT 11 Mice Lappaconitine hydrobromide oral pharmacokinetic study of Authors: Yan-Bin Shi, Xiu-Hua, Lv Dong, Guan Yu Zhu [Abstract] Objective To study the Lappaconitine hydrobromide in mice after oral pharmacokinetic properties. Methods HPLC determination of plasma concentration, using software processing MCPKP pharmacokinetic drug - time data. Results hydrobromide Lappaconitine blood concentration of 0.5 ~ 15 μ g * ml-1 within the linear relationship. In mice by 11.71 mg * kg-1 single dose oral administration, the main pharmacokinetic parameters: t1/2ka = 1.90 h, t1/2β = 4.31h, tmax = 0.94 h, Cmax = 2.40 μ g * ml-1, AUC = 20.89 μ g * h-1 * ml-1. Conclusion mice by oral Lappaconitine hydrobromide, the in vivo drug - when the process meets the two-compartment open model, absorb faster, eliminating moderate pace. [Keywords:] hydrobromide Lappaconitine; oral; pharmacokinetics Abstract: ObjectiveTo study the pharmacokinetics of lappaconite hydrobromide in mouse following oral administration.MethodsThe concentration of lappaconite hydrobromide in plasma sample was determined using HPLC method. The data of drug concentration-time were processed using a MCPKP programm. ResultsThe concentration of Lappaconite Hydrobromide in Mouse plasma had a good linear relationship within 0.5 ~ 15 μ g * ml-1 range. Lappaconite Hydrobromide was given to mice following oral administration at a single dose of 11.71 mg * kg-1. The main parameters were listed as follows: t1/2ka = 1.90 h, t1/2β = 4.31 h, tmax = 0.94 h, Cmax = 2.40 μ g * ml-1, AUC = 20.89 μ g * h-1 * ml-1. ConclusionThe results showed that drug concentration-time data of lappaconite hydrobromide in mouse plasma was fitted to a two-compartment open model. Lappaconite hydrobromide is absorbed rather quickly and eliminates moderately in mice. Keywords:Lappaconite hydrobromide; Oral administration; Pharmacokinetics Hydrobromide Lappaconitine (Lappaconite Hydrobromide) is extracted from high A