Modern treatment of hypertension.docVIP

 PAGE \* MERGEFORMAT 15 Modern treatment of hypertension In recent years, with a large-scale clinical trials to carry out anti-hypertension and cardiovascular molecular biology progress of the study, the conventional understanding of high blood pressure has been updated, evidence-based medicine has become a consensus. Hypertension is not only the hemodynamic disorders, but also accompanied by fat, sugar metabolism disorders and heart, brain, kidney and other target organs, adverse remodeling. Therefore, effective control of blood pressure treatment to the level of the same time, improve the various metabolic disorders, prevent and reverse the negative remodeling in target organs, which is to reduce the incidence and mortality of cardiovascular complications in the key. 1, hypertension, blood pressure goal Step-down objectives, namely the ideal blood pressure levels, blood pressure should be reduced to the greatest extent can be tolerated at this level, the lowest level of risk of cardiovascular complications. Dalby, GPPT, GBPCS and other follow-up study 3 to 10 years, the treatment group in hypertensive patients the occurrence of cardiovascular complications and death are still far higher than normal blood pressure with regional groups, the most likely explanation is that these patients received blood pressure drop is not the most appropriate, and therefore to achieve the desired blood pressure level is very important. What is the ideal target blood pressure levels? So far, the largest for a period of three years, HOT clinical trials have been successfully concluded, the results showed that blood pressure dropped to 138/83 mm Hg (1 mm Hg = 0.133 kPa), the occurrence of cardiovascular events the lowest rate. In addition, blood pressure dropped below this level is also very safe. 2, high blood pressure medication patients (A) Evaluation of anti-hypertension drugs 1. Diuretics: Europe and the United States a number of clinical trials, such as EWPHE, SHEP, ST