Modified Liu Wei Di Huang Tang on liver damage induced by cyclophosphamide in young rats protective effect of.doc

 PAGE \* MERGEFORMAT 14 Modified Liu Wei Di Huang Tang on liver damage induced by cyclophosphamide in young rats protective effect of Of: Jiangrong Yan, Zhu Liping, Chen Shuying, Liangxiu Ling, Li Ran Ran [Abstract] Objective Modified Liu Wei Di Huang Tang on liver damage induced by cyclophosphamide in the protection of young rats. Methods 2 and 3 weeks old Wistar rats was 32 #8203;#8203;weeks, each week a random number table segment was divided into 3 groups, control group 8 in the control group and experimental groups 12 12. experimental group was given Modified Liu Wei Di Huang Tang, 2 weeks old rats per each volume of the pharyngeal feeding 0.6 mL, 3 weeks feeding capacity of the pharyngeal per each 0.9 mL, 2 times a day, 14 d. consecutive weeks in rats fed control group, normal saline according to 2 times a day, continuous 14 d. experimental and control groups 7 and day 8 days of intraperitoneal injection of cyclophosphamide 100 mg / (kg · d); normal routine feeding, 7th and 8th day intraperitoneal injection of saline .3 groups were on the 15th day serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) levels. hematoxylin - eosin staining of liver histopathological changes observed. Results 2 weeks and 3 weeks in control rats ALT, AST were significantly higher than the normal group, the difference was significance (P lt;0.05), and the experimental group, ALT, AST were significantly lower than the control group, the difference was statistically significant (P lt;0.05); light microscope, liver cells in the control group with moderate to severe generalized degeneration of water, the experimental group significantly reduce the swelling of liver cells. Conclusion Modified Liu Wei Di Huang Tang on cyclophosphamide induced liver injury in young rats a protective effect. [Keywords:] Modified Liu Wei Di Huang Tang / therapeutic use; cyclophosphamide / poisoning; Liver / injuries; Rats, Wistar; animals, laboratory [Abstract] Objective To