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Multiple risk factors for diabetes control
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Multiple risk factors for diabetes control
[Keywords:] diabetes, multiple risk factors, control
Study confirmed that strict glycemic control can reduce the incidence of diabetic microangiopathy. But some studies found evidence-based medicine in the prevention of cardiovascular complications of diabetes, the only good blood glucose control is not enough, even controlling for other risk factors, it is because of diabetes As part of the metabolic syndrome, gathered a large number of risk factors for cardiovascular disease include high blood glucose, lipid metabolism disorders, hypertension, central obesity, and chronic inflammation, hypercoagulable state, etc., these risk factors for atherosclerosis in the arteries formation. insulin resistance metabolic syndrome exists as the soil, which is not only the occurrence of atherosclerosis in the initiating part, but also accelerated the development of atherosclerosis. At present the development of oral hypoglycemic agents, have begun to focus on its other hypoglycemic benefits of reducing cardiovascular disease risk factors.
1 antihyperglycemic effect of drugs on cardiovascular
Cardiovascular protective effect of metformin on plasma non-esterified fatty acids, including lower levels, improve blood lipids, reduce fat deposition in the vascular wall, inhibit vascular smooth muscle cell proliferation, anti-oxidative stress, lower blood viscosity and so on. Its beneficial cardiovascular role in the UKPDS study has confirmed. in the U.S. Diabetes Prevention Study (DPP found that metformin was also effective in treatment of central obesity, improve the response rate of metabolic syndrome.
Studies have shown that TZDs drugs thiazolidinediones (TZDs can decrease the blood of patients with type 2 diabetes small and dense low-density lipoprotein cholesterol, C-reactive protein, matrix metalloproteinase -9, plasminogen activator inhibitor -1 levels, increased high-density lipoprotein choleste
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