Mutations in the microbial biosynthesis of progress in drug research in the field.doc

 PAGE \* MERGEFORMAT 17 Mutations in the microbial biosynthesis of progress in drug research in the field Author: Bai Bao-Xing Zhang Chunyan Tian Min Zhu Hui Abstract mutations produce antibiotic biosynthesis as an important means of derivatives, since the 20th century, the rise since the 70s, played a significant role, has developed a number of so far is still widely used in clinical varieties of antibiotics. With the development of gene technology, mutation of the bio-synthesis technology can be directly secondary metabolic pathway in a specific gene to transform to obtain mutant strains, has greatly enhanced the efficiency and accuracy. In this paper, mutation of the biosynthesis of microbial agents in the field of applications, especially in connection with gene technology research carried out mutation of the biosynthesis of new development. Keywords: microbial agents Review on mutational biosynthesis in microbial medicinal fields ABSTRACT Mutational biosynthesis since its rising in1970’s, as a tool for the formation of antibiotic structural analogues, has played an important role and developed some novel derivatives which are still widely used in the clinic today.With the advance of gene engineering, mutants can be obtained by direct gene modifi-cation to certain enzyme in secondary metabolism pathway and efficiency is greatly promoted.In this paper, the progress, especially combining gene engineering of mutational biosynthesis is reviewed. KEY WORDS Mutational biosynthesis (MBS); Mutasynthon; Blocked mutant; Antibiotics The emergence of new diseases and the emergence of resistant strains are urgently call for a new development of bio-active substances. People in three main ways to obtain new active substances: ① the natural world; ② chemical synthesis and chemical transformation; ③ on producing bacteria to transform the secondary metabolic pathway to pathway changed in order to obtain new compounds, mainly of