Myeloperoxidase and severe asthma_0.doc

 PAGE \* MERGEFORMAT 15 Myeloperoxidase and severe asthma Of: Cui Jianying, Zhan Xiao Qin, Wang Wenjun [Keywords:] oxidative stress; myeloperoxidase; severe asthma; airway remodeling Asthma is a chronic airway inflammatory disease, a variety of inflammatory cells and cytokines involved in the disease, and increased oxidative stress, chronic inflammation and oxidative stress in the link has been shown between [1]. Severe Asthma neutrophils and eosinophils are involved in airway inflammation, but the neutrophils in the airway inflammation plays a decisive role. moderate to severe asthma patients induced sputum, bronchoalveolar lavage fluid (BALF) and mucosal tissues in increased and the infiltration of neutrophils [2]. myeloid peroxide compounds enzyme ((myeloperoxidase, MPO) in the secretion of neutrophil activation, is considered a significant symbol inflammatory response, involved in oxidative stress [3], in severe pathogenesis of asthma is important. This article about recent research and MPO’s role in severe asthma do a review. 1 MPO source, structure and biological function MPO is a heme peroxidase - a member of the superfamily of cyclooxygenase, including heme, is glycosylated hemoglobin tetramer protein glycosylation by the two 59 - to 64-KD heavy chain and two non-glycosylated light chain composition, molecular weight 150000.MPO gene is located on human chromosome 17 (17p13),; differentiation in the bone marrow synthesis of a large number of neutrophils in the expression Neutrophils are addicted to the main component of azure granules, neutrophils accounted for 5% of total cell protein. neutrophil secretion of total circulating MPO content of 95%. there is very little part of the MPO in monocytes cells and macrophages present. MPO in the neutrophil respiratory burst off into the phage particle secretion when a large number of cell bodies and space, through autocrine or paracrine further activation of neutrophils. MPO activity was unique