Mutagenicity of anticancer drugs and Clofarabine Study hemolytic.doc

 PAGE \* MERGEFORMAT 16 Mutagenicity of anticancer drugs and Clofarabine Study hemolytic Of: Li Xinhua, Sun Xin Xin, Cui Fei, Xiao-Yan Wang, Yuan side [Abstract] Objective Clofarabine (referred to as CLO) on bone marrow red blood cells and germ cells of male mice with or without mutagenic and teratogenic effects, and whether the dissolution of the peripheral red blood cells. Methods micronucleus test on bone marrow RBC CLO mutagenicity, the use of sperm abnormality test in mice germ cells CLO teratogenic effects, the use of human red blood cells hemolytic CLO test. Results The micronucleus test, CLO test group and the positive control group between the two groups was not significant (Pgt; 0.01), with the negative control group difference was significant (P lt;0.05). sperm abnormality test, CLO test group and positive control group showed no significant (Pgt; 0.05), but with the negative control group There was a significant difference between (P lt;0.01). CLO in vitro dissolution of human red blood cells not the time. Conclusion The test, CLO with other anticancer drugs such as oligonucleotides, can lead to strong cell proliferation in vivo mutations, and the distortion of germ cells; on the solubility of human red blood cells were negative. [Keywords:] Clofarabine; micronucleus test; sperm aberration; hemolytic; teratogenic; mutagenic Most of the pharmacological effects of anti-leukemia drug is based on inhibition of tumor cell DNA synthesis and the role of inhibition of some of the polymerase to prevent the proliferation of tumor cells characterized. So, the World Health Organization (WHO) had announced: starting from the DNA is the key to the treatment of cancer . Clofarabine (referred to as CLO) that is the case, as a ribonucleotide reductase inhibitor, DNA synthesis in tumor cells can be terminated to the role of killing tumor cells [1], then the normal body’s reproductive cells, bone marrow erythrocytes and peripheral blood erythrocytes of wha