Neural tube defects in experimental study of sciatic nerve repair.doc

 PAGE \* MERGEFORMAT 11 Neural tube defects in experimental study of sciatic nerve repair Of: Feng-long Zhao Zhiying Liu Qi Huang Lihua [Abstract] Objective: Using a self developed with good biocompatibility of chitosan to repair the building of artificial neural rat sciatic nerve defect, studies confirm that the repair effect. Methods: 30 healthy male Wistar rats were randomly divided the normal control group (A group, in situ nerve group (B group, chitosan nerve conduit bridging group (C group) 3 group, cut off the sciatic nerve were accordingly dealt after 12 weeks of nerve electrophysiological testing. Results : C group 12 weeks after nerve section has been longer than the defect, nerve conduction recovery. Conclusion: This casing can be effectively bridged 10 mm long sciatic nerve defect, can be used in the treatment of peripheral nerve defects at the same time as Further development of artificial neural tissue engineering a good carrier. [Keywords:] neural tube, peripheral nerve, defects, chitosan Abstract Objective: Using a self-developed chitosan with good biocompatibility to build artificial nerves to repair defects in rat’s sciatic nerve and a study was made to confirm the repair effect. Methods: 30 healthy male Wistar rats were randomly divided into 3 groups (A: normal control group, B: in situ nerve graft group, C: Artificial neural bridge group). Sciatic nerve were cut off with the deal accordingly, 12 weeks later, the nerve electrophysiological testing was performed. Results: 12 weeks later, the nerve has been a long paragraph defect, the function of nerve conduction recovered. Conclusion: This casing can effectively bridge the Sciatic Nerve defect of 10mm in rats and can be used in the treatment of peripheral nerve defects. At the same time it can serve as a good carrier for the further development of tissue-engineered artificial nerves. Keywords: Nerve conduit; Peripheral nerve; Defect; Chitosan Peripheral nerve injury in clini