Non-small cell lung cancer the expression of estrogen receptors and endocrine therapy.doc

 PAGE \* MERGEFORMAT 14 Non-small cell lung cancer the expression of estrogen receptors and endocrine therapy [Keywords:] lung cancer; non-small cell lung cancer; estrogen receptor; endocrine therapy Lung cancer is one of the most common malignancy worldwide, and the incidence increased year by year, cancer in the country has become the first male and female malignancy in the first two, male and female cancer mortality in the first place. Despite surgery, radiotherapy and chemotherapy combined therapy, the survival rate remains low, it is necessary to find new treatments. sex hormone receptor status and its impact on a variety of tumors, development and prognosis. in adult tumors, the prognosis of breast cancer, estrogen hormone receptors (estrogen receptor, ER) status has obvious relevance in breast carcinoma estrogen and progesterone receptor status determine the prognosis of breast cancer is an important basis and hormone therapy. As early as 1955, Olson [1] to reported in lung cancer and the existence of a hormone acting factors, and made available steroid therapy. Beattie et al [2] proposed in 1985 patients with normal lung tissue and lung cancer exists in both the estrogen receptor, hormone receptor in lung cancer significantly higher than normal, lung cancer is hormone-dependent tumors presented. So far, the ER expression in lung cancer and its significance is still much controversy. Detection of current ER tumors of endocrine therapy has become the focus of the medical profession directions. 1 ER and lung cancer 1.1 ER ER structure and mechanism of action is a glycoprotein, human ER amino acid sequence is 595, relative molecular mass of about 260 000, there are three basic domains, N terminal with the transcriptional activity of the regulatory domain, C, is the central DNA binding domain, C terminal area is the hormone binding domain E. ER concentration in the cell is very low, accounting for 0.01% of total cellular protein below a certain c