Noninvasive quantitative ultrasound integral relationship between liver fibrosis and Experimental Research.docVIP

 PAGE \* MERGEFORMAT 10 Noninvasive quantitative ultrasound integral relationship between liver fibrosis and Experimental Research [Abstract] Objective: To develop a healthy male SD rat liver fibrosis model of liver fibrosis in non-invasive ultrasound in the diagnosis of quantification. METHODS: at 0 week, 2 weeks, 4 weeks, respectively, a composite factor for the establishment of 27 healthy SD male rat liver fibrosis model of liver histopathology, ultrasonography and serum fibrosis markers examined to pathological diagnosis as the standard integration of ultrasonic non-invasive quantification of liver fibrosis diagnosis. Results: The success of a composite factor method rat liver fibrosis model was established, experiments show that ultrasound and pathological points good correlation of liver fibrosis stage, ultrasound total score and serum liver fibrosis markers in the application, make an early diagnosis of liver cirrhosis increased the sensitivity and specificity. Conclusion : Ultrasound and Ultrasound points and serum liver fibrosis markers in non-invasive application of quantitative diagnosis of liver fibrosis have a higher value. [Keywords:] liver fibrosis; pathological examination; ultrasonography; integration scheme Liver biopsy examination is considered to determine the gold standard for liver fibrosis, at present, there are conventional implementation of the biopsy very difficult to find non-invasive quantitative diagnosis of liver fibrosis in an effective way to much attention in liver fibrosis [ 1-2]. In this experiment rat liver fibrosis model for the study is to explore non-invasive ultrasound quantification of liver fibrosis diagnosis. 1 Subjects and methods 1.1 for male animals, 35 SD rats, weight 150 ~ 220g, average 180g, were randomly divided into five groups, a compound factor induced fibrosis model approach, the establishment of rat liver fibrosis. Modeling methods: (1 to 79.5% pure corn meal plus 20% lard, 0.5% cholesterol i