Nu land available for alcohol and opioid receptor analgesic effect of the relationship between the.doc

 PAGE \* MERGEFORMAT 6 Nu land available for alcohol and opioid receptor analgesic effect of the relationship between the [Abstract] Objective To study the Nu to be the analgesic effect of alcohol and opioid receptor relationship. Methods Kunming mice were randomly divided into Nu to be alcohol 10 mg * kg-1 group, naloxone 5 mg * kg-1 Nu to be alcohol 10 mg * kg-1 group, morphine 7.5 mg * kg-1 group, Naloxone 5 mg * kg-1 + morphine 7.5 mg * kg-1 group and the saline control group. Both subcutaneous administration. In mice writhing, hot plate 30 min after the drug was observed in each group the number of mice writhing and hot-plate test 30,60,90 min after drug pain threshold. Results 10 mg * kg-1 Nu land available for alcohol can significantly reduce the number of writhing increase pain threshold, compared with the saline group differences (P amp;lt;0.01). Naloxone significantly antagonized the analgesic effect of morphine, but there could be Nu analgesic effect of alcohol had no significant effect. Conclusion Nu places can not by alcohol’s analgesic effect of opioid receptor-mediated. [Keywords:] Nu to be alcohol; analgesic; naloxone; opioid receptor The Relationship between Analgesic Effect of Nudicaulol and Opium Acceptors Abstract: ObjectiveTo explore the relationship between analgesic effect of Nudicaulol and opium acceptor. MethodsThe mice were randomly divided into 10 mg * kg-1 Nudicaulol group, 5 mg * kg-1 Naloxone 10 mg * kg-1 Nudicaulol group, 7.5 mg * kg -1 Morphine Hydrochloride group, 5 mg * kg-1 Naloxone 7.5 mg * kg-1Morphine Hydrochloride group and saline control group. The relationship between analgesic effect of Nudicaulol and opium acceptor was investigated by writhing test, hot plate test (55 ℃ ) in mice. ResultsIn the writhing test, 10 mg * kg-1 of Nudicaulol significantly reduced the number of writhing induced by ip 0.05% antimony potassium tartrate, in the hot plate test, 10 mg * kg-1 of Nudicaulol significantly enhance