Omeprazole and famotidine in the prevention of acute cerebrovascular disease and the effect of stress ulcer bleeding.docVIP

Omeprazole and famotidine in the prevention of acute cerebrovascular disease and the effect of stress ulcer bleeding [Keywords:] Losec; famotidine; Cerebrovascular disease; stress ulcer; Prevention Has been reported, acute cerebrovascular disease and the incidence of stress ulcer bleeding was 18.2% ~ 84.0% (1), which occurred hours after the onset is usually in the 1 ~ 8 d, so clinical when admitted patients with acute cerebrovascular disease not only to active treatment of the primary disease, should also be strengthened stress ulcer prophylaxis to reduce mortality in acute cerebrovascular disease (2). The applications were omeprazole (Losec) and famotidine prevention of acute cerebrovascular disease patients with stress ulcer bleeding, and compare its efficacy. 1 Materials and Methods 1.1 General information select from February 2005 to November 2009 in our hospital 94 patients hospitalized with acute cerebrovascular disease as the object of study, with reference to the Fourth National Cerebrovascular Disease Academic Meeting to develop diagnostic criteria: Agegt; = 60 years old, no previous peptic ulcer disease, liver disease, history of hemorrhagic disease; onset were admitted to hospital within 12 h; were confirmed by CT or MRI diagnosed with acute cerebrovascular disease; There was no hematemesis or before admission Black has symptoms; admission obvious neurological signs and different degrees of localization of consciousness, Glasgow coma scale (GCS) 8 points; line before admission and before discharge blood, liver function, blood coagulation and the three gastric occult blood trial patients were randomly divided into two checks .94 omeprazole and famotidine group group, 47 patients in each group. the two groups showed no significant general information difference (Pgt; 0.05), see Table 1. Table 1 General information groups Comparison 1.2 Stress Ulcer of the diagnostic criteria are the original cause of stress ulcer disease exists; exc