On behalf of exogenous nucleotide safety evaluation of development.docVIP

 PAGE \* MERGEFORMAT 13 On behalf of exogenous nucleotide safety evaluation of development Of: Ma Yi Xu Linlin Xu Yajun Li Yong [Abstract] Objective propagation through three generations, the effect of exogenous nucleotides for the rodent rat fertility and offspring physical, neurological and development of indicators to make the development of safety evaluation. Methods SD rats (F0 generation) off milk, feed the nucleotide contents were 0,0.01%, 0.04%, 0.16%, 0.64%, 1.28% of the test substance after 90 d feed the male and female mating 1:1, the litter size in mice to Fl; Fl 90 d after weaning feeding after the second-generation reproduction test. repeat the experiments until the end of the experiment several generations of breeding, F3 generation of birth; parental generation rats were observed during pregnancy, childbirth, lactation and the offspring of lactating case situation, Indicators of physical development, reflex index. the result of exogenous nucleotides not complementary to parental rats during pregnancy, childbirth, lactation and the offspring of lactating rats, physiological and neurological development reflected unusual circumstances. Conclusions In this study, doses of exogenous added nucleotides for additional multi-generation rat reproductive function and embryonic, fetal development and lactation is safe. [Keywords:] Nucleotide; development; security [Abstract] Objective To investigate the effect of exogenous nucleotides on fertility in parents rats and the indexes of physiological and neural development in newborn rats over the three-reproductive experiment, and evaluate the safety on development.MethodsWeanling rats (F0) were fed to exogenous nucleotides at the dose of 0, 0.01%, 0.04%, 0.16%, 0.64%, 1.28% for 90 days and then male and female rats mated for 1:1 pattern. The offspring of F0 was F1. F1 rats were fed to exogenous nucleotides for 90 days after they were weaned. And then these rants go on to the second reproductive ex