Oleander safflower safflower and Loranthaceae parasitic lethal dose determination in mice.docVIP

 PAGE \* MERGEFORMAT 5 Oleander safflower safflower and Loranthaceae parasitic lethal dose determination in mice [Abstract] Objective To study the red flower oleander, safflower, and Loranthaceae parasitic on mice of the half lethal dose (LD50). Methods to mice fed a one-time observed in mice within 7 d of toxic reactions and death, to mice with acute mortality as an indicator, seeking oleander safflower, safflower, and parasitic Loranthaceae three kinds of drugs on the mouse LD50 and the LD50 of the 95% confidence limits. Results oleander safflower, safflower, and Loranthaceae parasitic LD50 in mice were 16.78,91.75, 129.41 g * kg-1. Conclusion safflower oleander the most toxic, followed by safflower parasitic Loranthaceae minimal toxicity. [Keywords:] Safflower oleander; Safflower parasitic; Loranthaceae; mouse; half of the lethal dose Abstract: ObjectiveTo determine the half-lethal dose (LD50) of three Chinese crude drugs, Nerium indicum Mill, Scurru-la parasitica Lim and Taxillus chinensis (DC) Danser in mice.MethodsThe drugs were given to mice intragastrically (ig.) only once . The toxic reaction and death of mice 7days after ig. administration were obsened, and the LD50 and 95% confidence interval of 3 drugs weremeasured with acute mortality rate as index. ResultsThe LD50 of Nerium indi cum Mill, Scurru-La Parasitica Lim and Taxillus Chinensis (DC) Danser was 16.7, 91.74 and 129.41 g * kg-1, respectively.ConclusionNerium indicum Mill is the most toxic, Scurru-La Parasitica Lim takes the second place, and Taxillus chinensis (DC) Danser is the least toxic. Keywords:: Nerium indicum Mill; Scurru-la parasitica Lim; Taxillus chinensis (DC) Danser; Mice; LD50 Safflower oleander Nerium indicum Mill its leaves contain oleander glycosides, glycosides and other substances, there are more significant role in the strong heart, bitter, cold, toxic, naturalization Heart Sutra [1], modern energy for the treatment of clinical failure, wheezing cough, bruises, amen