Oleanolic acid and ursolic acid asiatic acid Liver Comparison of antioxidant effects_0.docVIP

 PAGE \* MERGEFORMAT 14 Oleanolic acid and ursolic acid asiatic acid Liver Comparison of antioxidant effects Of: Tang Xinhui, Yanli Fang, Xu Haw, Gao Jing [Abstract] Objective To study compared three kinds of pentacyclic triterpenoids oleanolic acid (OA), ursolic acid (UA), asiatic acid (AA) of the liver protection and antioxidant effect. Methods D-amino-half of mice Gal / LPS (D-GalN/LPS) liver injury model, testing OA, UA, AA serum on the injury aspartate aminotransferase (AST), alanine aminotransferase (ALT) activity and liver lipid peroxidation; the use of in vitro free radical scavenging, Determination of 3 compounds on superoxide anion and hydroxyl radical scavenging. Results 100 mg · kg-1 OA, UA, AA can inhibit the D-GalN / LPS induced serum AST and ALT activity increased significantly; significantly reduced lipid peroxidation in liver tissue MDA generation; a certain concentration of three kinds of compounds are effective superoxide anion and hydroxyl radical, and free radical scavenging compounds 3 There were significant differences in ability. Conclusion three kinds of pentacyclic triterpenoids OA, UA, AA were significant hepatoprotective and antioxidant activity, and AA, UA’s Liver better than that of OA, its mechanism may be removed with more freedom base capacity. [Keywords:] oleanolic acid; ursolic acid; asiatic acid; D-galactosamine / lipopolysaccharide; antioxidant Abstract: ObjectiveTo compare the hepatoprotective and anti-oxidative effects of three pentacyclic triterpenoids, oleanolic acid (OA), ursolic acid (UA) and asiatic acid (AA). MethodsD-GalN/LPS-induced liver injury model was used to evaluate the effects of OA, UA and AA on the activities of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and the level of liver lipid peroxidation in mice. Scavenging activity on superoxide anion and hydroxyl radicals of three compounds were investigated to determine their anti- oxidative effects.ResultsPretreatment