Oleander on the heart contraction of frog and its mechanism.docVIP

 PAGE \* MERGEFORMAT 7 Oleander on the heart contraction of frog and its mechanism [Abstract] Objective To investigate the toxicity of different doses of oleander and K (poison lanatoside (glycosides) K on the toad heart and its related mechanisms. Methods isolated toad heart, containing sodium pentobarbital (2mmol / L, 1ml of Ringer solution caused toad heart failure model (lower half of myocardial contractility as heart failure, the tension transducer, BL-410 Smart Display and biological signal processing system records the activities of myocardial contraction as the control curve .5 min group, and then observed its effect of drug, 2min after the curve, and compared with the control group. oleander results of perfusion solution of different concentrations, the 2% of the oleander solution (0.2ml) within 2min of myocardial contraction frequency in the rapidly strengthened, the rates are the maximum, 10min after the frequency and amplitude of myocardial contraction and then decreased slowly returned to the control group. and 2% (0.2ml) of the drug K continuous observation 2min, 5min, 8min no change in frequency of myocardial contractility. Conclusion certain concentration oleander solution on myocardial contractile force and amplitude have been strengthened, and the same concentration of drug at the same time the rate and extent of myocardial contraction K in a straight line, a 2% increase in myocardial contractile oleander solution rate and magnitude of effect was stronger shorter, while the drug K for a long time, high dose. the difference was significant. Conclusion 2% of the oleander solution on myocardial contractile force and amplitude are enhanced, while the drug treatment was close to K 60% of the poisoning. [Keywords:] Heart Medical oleander Toad of Toad [Abstract] Objective: Finding out the impact and the relevant mechanism of different dosages of oleander and Strophanthin k on the heart of toad; Approach: Forming a heart-failure model maki