Overview of targeted therapy of ovarian cancer Progress.docVIP

 PAGE \* MERGEFORMAT 30 Overview of targeted therapy of ovarian cancer Progress [Paper Keywords:] of molecular targeted therapy of ovarian cancer chemotherapy clinical trials of drug-resistant [Abstract] Chemotherapy is an important means of ovarian cancer, but ovarian cancer cells to chemotherapeutic drugs such as cis-platinum resistant ovarian cancer MDR, as well as targeted therapy is becoming increasingly fierce, a large number of clinical trials have been carried out by a single agents targeted drugs, targeted chemotherapy, targeting various aspects of the joint targeting of ovarian cancer to seek more treatment, diagnosis and prognostic factors also have a new found to seek more targets for the treatment of ovarian cancer and the corresponding target to the treatment of ovarian cancer patients particularly important. . In recent years, ovarian cancer clinics, there have been many new progress. Ovarian cancer in female genital cancer incidence rate in the third place, but the fatality rate was ranked 1 [1]. Early symptoms of ovarian cancer because of the clinical, line laparotomy in ovarian tumor was found confined to only 30%, most of the bilateral annex has spread to the uterus, omentum and pelvic organs. Combined platinum-and paclitaxel is currently the treatment of refractory ovarian cancer, the preferred program, but most patients there is resistance to platinum drugs [2]. To improve the therapeutic effect, we should start at the molecular level understanding of resistance mechanisms to chemotherapy of ovarian cancer and to find a more effective role in drug resistance in ovarian cancer targets. This article summarized a recent research done. 1. Ovarian Cancer Chemotherapy The chemical treatment of ovarian cancer 60 years from the last century, the alkylating agent to 70 to 80 years of platinum-group, to 90 years of taxol, and constantly progress. Vieira, addressing the platinum-sensitive (via platinum untreated relapse after ≥ 12 months) ovaria