p53 and HPV-related cervical cancer.docVIP

 PAGE \* MERGEFORMAT 21 p53 and HPV-related cervical cancer Keywords: cervical cancer; p53; HPV; treatment Cervical cancer is a common malignancy of women, ranking the female reproductive system malignancies second place every year 370 000 new cases, and about 190 000 women die of this disease. In recent years, due to the survey and advances in treatment of cervical injury, cervical cancer incidence and mortality in developed countries dropped significantly; developing countries, the incidence of cervical cancer in women, accounting for about 20% to 30%, is still a threat to women’s health One of the main issues. Therefore, cervical cancer etiology, pathogenesis and therapy research by scholars at home and abroad are highly valued. 1 HPV and cervical cancer Molecular epidemiology has made it clear that high-risk human papilloma virus (Human papillomavirus, HPV) is the major risk factors of cervical cancer. In almost all cervical squamous cell carcinoma (greater than 99.7%) and greater than 70% of cervical adenocarcinoma can be detected HPV [1]. Has found that more than 130 kinds of HPV subtypes, about 40 infected with the reproductive system, these subtypes, including low-risk type HPV6, 11,40,42,43,44,54,61,70,72,81, and CP6108; and high-risk -type HPV16, 18,31,33,35,39,45,51,52,56,59,68,73 and 82 [2]. One high-risk HPV16 and 18, and the incidence of cervical cancer the most relevant. HPV gene for the closed-loop double-stranded DNA, a diameter of about 55nm, a length of about 7.9kb, only a chain-code open reading frame (ORFs), by the early genes (E), late gene (L) and non-coding region (upstream regulatory region or length control area) formed. The early genes E1, E2, E4, E5, E6 and E7, these genes early in viral infection the body expression and regulation of viral DNA replication, translation and cell cycle of transformation functions. In which E6 and E7 in cell immortalization and transformation of the role of the