P2X4 Receptors and Neuropathic Pain Research Progress.docVIP

 PAGE \* MERGEFORMAT 12 P2X4 Receptors and Neuropathic Pain Research Progress [Abstract] Neuropathic pain is caused by nervous system injury in a chronic pain, its pathogenesis complex, to date still lack of effective treatments. Recent studies have shown that the spinal cord dorsal horn of nerve root activated microglia expressed P2X4 receptors in neuropathic pain has an important role in suggesting may be involved in the pathogenesis of neuropathic pain, this article on the P2X4 receptor in neuropathic The role of pain are reviewed. [Keywords:] neuropathic pain; P2X4 receptor; microglia Neuropathic pain (neuropathic pain) is the primary or secondary to nervous system damage, dysfunction caused by pain, such as surgery, bone compression, diabetes and infections. Common symptoms of neuropathic pain: spontaneous pain (stimulus  independent of pain), abnormal pain (allodynia), hyperalgesia (hyperalgesia). So far, the incidence of neuropathic pain, the exact mechanism is not clear that the possible mechanisms include peripheral production of abnormal afferent impulses; sodium, potassium, calcium ion channel changes; as well as NMDA receptors, P substance, and so activation. Recent studies have found that the activation of microglia in the occurrence of neuropathic pain has an important role in the activation of microglia in P2X4 receptor expression in the process significantly increased, suggesting that P2X4 receptors may be involved in neuropathic caused pain [1]. In this paper, P2X4 receptors in the role of neuropathic pain are reviewed. 1 purinergic receptor P2X4 receptor 3 Adenosine (ATP) is the body most directly is the most important energy supply of material at the same time study also found that ATP can serve as an important signaling molecule acting on the surface of activated microglia through purinergic receptors play a role in central nervous system and peripheral nerve pain, the mechanism [2]. ATP receptors (receptors for purines and pyrimidine