Pancreatic CXCL12-CXCR4 biological axis and the expression of VEGF-C and correlation.docVIP

 PAGE \* MERGEFORMAT 12 Pancreatic CXCL12-CXCR4 biological axis and the expression of VEGF-C and correlation Of: Yu Zhang Fei Li-Ming Wang Changliang Zhao Huazhang Bo Sheng Zhou Wen-Yuan Wu Zhongwei Xia Li Sheng [Abstract] Objective: To study the pancreatic CXCL12-CXCR4 biological axis (CXCL12-CXCR4 biological axis and vascular endothelial growth factor-C (vascular endothelial growth factor-C, VEGF-C expression to investigate the expression and pancreatic cancer Clinical Pathology. Methods: Immunohistochemistry and RT-PCR detected 30 cases of pancreatic cancer, adjacent normal pancreas and pancreatic lymph node tissues of CXCL12, CXCR4, and VEGF-C expression. Results: CXCL12 protein in pancreatic cancer the state tissue was low expression in normal pancreas, pancreatic cancer tissues and lymph node tissues showed moderate expression status (P lt;0.01, RT-PCR results also confirmed this result, and pancreatic cancer tissues were compared between statistically significant (P lt;0.01.CXCR4 protein in pancreatic cancer, pancreatic cancer tissues and lymph node status showed high expression in normal pancreatic tissues showed low expression of the state, RT-PCR results also confirmed. The Spearman test CXCR4 in pancreatic cancer with VEGF-C expression correlated significantly (P = 0.038. Conclusion: CXCR4 expression and lymph node metastasis of pancreatic cancer, its high expression on pancreatic lymphatic vessel may promote the formation of role. CXCR4 in pancreatic cancer with VEGF-C expression correlated significantly, both may be pancreatic cancer lymphangiogenesis and lymph node metastasis of synergy. [Keywords:] pancreatic tumor CXCL12 CXCR4 vascular endothelial growth factor [ABSTRACT] Objective: To investigate the expression of CXCL12-CXCR4 and VEGF-C in pancreatic cancer and relation to clinical pathology. Methods: The tissue samples including PAC, the cancerous peripheral tissues, the normal pancreatic tissues and peripheral lympho nodes w