p16INK4a and Progress in the relationship between gynecological malignancies.docVIP

 PAGE \* MERGEFORMAT 16 p16INK4a and Progress in the relationship between gynecological malignancies [Abstract] p16INK4a gene is a tumor suppressor gene, in CyclinD CDK4 / 6 pRb E2F pathway play an important role in negative feedback regulation, most of the malignant tumors were found in the expression of the gene deletion. P16INK4a expression in ovarian cancer with low adverse prognostic index can be used as an independent prognostic factor of ovarian cancer; p16INK4a expression in cervical cancer was over to help cervical cancer screening; p16INK4a in endometrial cancer development plays an important role in metastasis of endometrial carcinoma occurred closely related to the rate of increase; in vulvar HPV infection type, the frequent overexpression of p16INK4a is a reliable marker for HPV-positive vulvar cancer. [Keywords:] pl6INK4a; ovarian cancer; cervical cancer; endometrial cancer; vulvar cancer Oncogenes and tumor suppressor genes on the cell cycle of positive and negative feedback regulation of cell mutation and cancer control is an important mechanism in place [1]. P16INK4a gene is a direct effect was found in the cell cycle, inhibit cell division inhibition oncogene in CyclinD1 CDK4 / 6 pRb E2F pathway play an important role in negative feedback [2]. As the gene product of the cyclin-dependent kinase inhibit the activity of CDK4, which is also known as INK4 (inhibitor of CDK4) gene [3]. In most malignant tumors were found in the expression of the gene deletion, but in gynecological tumors p16INK4a gene inactivation and expression is not the same, and gynecological tumors, development and prognosis. Therefore, Detection of expression of p16INK4a in diagnosis and treatment of gynecological tumors has important clinical significance. 1 p16INK4a gene structure and function of the product pl6INK4a gene located on chromosome 9p21, total length of about 8.5kb, from 3 exons and 2 introns, the gene locus is a rare overlap coding loci, consistin