Pediatric cardiopulmonary bypass on postoperative inflammatory response.docVIP

 PAGE \* MERGEFORMAT 12 Pediatric cardiopulmonary bypass on postoperative inflammatory response [Abstract] Objective To investigate the cardiopulmonary bypass on cytokines in children with congenital heart disease and C reactive protein. Methods The experiment divided into two groups, the cardiopulmonary bypass group (A group) for the study, 26 patients with left to right shunt children with congenital heart disease, undergoing elective open heart cardiopulmonary bypass surgery for congenital heart disease; random sample of the same period non-cardiopulmonary bypass in children with thoracic or abdominal surgery, 30 cases of the control group (B group). two taken at different time points in children with central venous blood, using enzyme-linked immunosorbent assay (ELISA) determination of tumor necrosis factor - @ (TNF-@), interleukin -6 (IL-6), Interleukin -8 (IL -8), interleukin -10 (IL-10) and C-reactive protein (CRP) levels. Results A group of TNF-@, IL-6, IL-8 in after 2 h, 24 h respectively, the two peaks , IL-10 at a peak after 2 h, 48 h were decreased to normal; B group TNF-@, IL-6, IL-8, IL-10 are the peak after 2 h, 48 h decreased to normal; two CRP were at a peak after 24 h, 48 h was still higher than normal; parameter amplitude in group A more significant (P lt;0.05 or P lt;0.01). Conclusion cardiopulmonary bypass in children undergoing open heart congenital heart disease can lead to TNF-@, IL-6, IL-8, IL-10, CRP and other pro-inflammatory and anti-inflammatory mediators released in the cardiopulmonary bypass-induced systemic inflammatory response may play an important role. [Keywords:] cardiopulmonary bypass; congenital heart disease; cell factor; C-reactive protein Abstract: Objective To study the impact of peripheral blood cytokines and creactive protein in children with congenital heart disease by cardiopulmonary bypass. Methods Patients were divided into two groups, and 26 cases of children with left-to-right shunt congenital heart di