Phytoestrogens and their role in the progress of targets.doc

 PAGE \* MERGEFORMAT 13 Phytoestrogens and their role in the progress of targets [Keywords:], estrogen receptor [Keywords:] female hormones; role of the target; estrogen receptor Progress in research on phytoestrogens and their effect targets Since the first published Setchell and Adlercreutz isoflavones and wood body and mammals, estrogen ester structure similarity, and describes the role they may have anti-cancer since the phytoestrogens subjected to extensive attention [1]. At present, the use of estrogen replacement therapy for menopausal syndrome, osteoporosis, senile dementia and other diseases have achieved good effect. However, there are long-term use of estrogen-induced breast cancer, endometrial cancer and pulmonary embolism risk. The study of plant estrogens to find effective and safe for human estrogen-dependent diseases, treatments demonstrated a new perspective. In this paper, the role of phytoestrogens and their targets of research are reviewed. An estrogen receptor Estrogen receptor (estrogen receptor, ER) belong to large family of steroid hormone receptors to the form of oligosaccharides in the cytoplasm, once with the formation of estrogen-binding activity of monomer that is rapidly transferred from the cytoplasm to the cell the nucleus, and nuclei-specific DNA sequence on the estrogen-responsive element binding, thereby activating the hormone-dependent gene transcription, translation, synthesis of proteins and, ultimately, cell division, reproduction and growth [2]. ER has two subtypes, namely ERα and ERβ . Since 1986, cloned ERα , 1996 Nian Kuiper et al [3] from the rat ovary and prostate cDNA library has been successfully cloned ERβ , it is the structure of these two ER subtypes and distribution of already have a more comprehensive understanding. 1.1ERα the structure of ERα and ERβ , and ERβ protein molecules from the N porting is divided into A, B, C, D, E, F, and include A / B zones are transcriptional regulatory region involve