Pigment epithelium-derived factor and diabetic nephropathy.doc

 PAGE \* MERGEFORMAT 17 Pigment epithelium-derived factor and diabetic nephropathy Keywords: pigment epithelium derived factor; diabetes; diabetic nephropathy; microvascular complications Diabetic nephropathy (DN) in diabetic (DM) is one important microvascular complications, the number of patients increased year by year, as end-stage renal disease and major cause of death in patients with DM. U.S. Renal Data System (United States Renal Data System, USRDS) 1 statistics show more than 30% of end-stage renal failure (ESRF) due to DN, 2030, DM will reach 360 million patients around nearly 40% of the patients developed DN. DN prevention has become a serious problem. In recent years, with the cell biology and molecular biology techniques in-depth research, scholars began to study attention and cytokines in the DN role. Pigment epithelium derived factor (pigment epithelium derived factor, PEDF) is a recent discovery of a powerful angiogenesis inhibitor, has neurotrophic protection, regulation of vascular permeability and effective inhibition of angiogenesis and so on. Previous studies is more PEDF and Diabetic Retinopathy (diabetic retinopathy, DR) relationship. In recent years about the relationship between PEDF and the DN in the DN study confirmed that PEDF also play a useful role in 2. In this paper, the role of PEDF in the DN reviewed the research progress. 1 PEDF and Biological Function Overview 1.1 PEDF Overview PEDF 1989 Tombran Tink other for the first time in cultured human fetal retinal pigment epithelial cells found in the media activity of a nerve factor, can induce retinoblastoma Y 79 cells to mature neurons. It is super-gene family of serine protease inhibitors, but no inhibition of the role of proteolytic activity 3. PEDF contains 418 amino acids, is the molecular weight of about 50 kD glycoprotein. Encoded by a single gene, located on chromosome 17p13, gene is 16 kb, consists of 8 exons and 7 introns. When 17 weeks in huma