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Pharmacokinetics of berberine Research.doc

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Pharmacokinetics of berberine Research

 PAGE \* MERGEFORMAT 5 Pharmacokinetics of berberine Research Author: Lan-Fang Li Meng Junhua Wu Yujuan [Abstract] an overview of berberine in animal and human body’s absorption, distribution, metabolism, excretion and other pharmacokinetic data for the pharmacokinetic study of berberine for reference. [Keywords:] Summary of the pharmacokinetics of berberine Berberine, also known as berberine (Berberine), is a traditional Chinese medicine berberine main active ingredients, has been in clinical medicine as an anti-bacterial diarrhea. In recent years, with in-depth study of its clinical use has been extended to cardiovascular disease, diabetes, etc. [1]. Pharmacokinetic study of berberine are also increasingly in-depth, current overview on the recent studies are summarized below. A detection method 1.1 High Performance Liquid Chromatography 1.1.1 normal phase high performance liquid chromatography with fluorescence detection method Rusen [2] According to the halogenated hydrocarbons such as solvents in the berberine in the UV excitation can produce a strong fluorescence of this feature, using normal phase chromatography - fluorescence detection method greatly improves the detection sensitivity of detection of berberine. 1.1.2 RP-HPLC berberine pK of 2.47 [3], according to the theory of solute ionization, when the mobile phase pHpK, the alkaloid in neutral state of solute mainly retained in the carbon column 18 to enhance ; as the mobile phase pH ≈ pK, the retention time along with the small changes in pH and sensitive changes, will bring good reproducibility of chromatographic separation. The mobile phase pH is generally not use pH2 ~ 3 [4]. YU Chen [5] and so on with the DL-Camphor -10 - acid do ion-pair reagent, was established in the berberine in plasma by RP-ion-pair chromatographic method. With the DL-Camphor -10 - acid concentration increased, the value of increased retention of berberine. Is superior to ion-pair reagent n-heptane sulfonic acid and

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