Polygonum butanol extract on cardiac hypertrophy sodium potassium and calcium activity of ATP.docVIP

 PAGE \* MERGEFORMAT 10 Polygonum butanol extract on cardiac hypertrophy sodium potassium and calcium activity of ATP Of: Zhi-Hua Huang, Li Liangdong has Jing, Lin Huaiming, Huang Xianhua [Abstract] Objective To observe Polygonum butanol extract of isoproterenol (Iso) induced protective effect of cardiac hypertrophy and its Na +-K +-ATPase, Ca2 +-ATPase, CK, LDH activity. Methods by Iso 1mg kg-1 d-1, subcutaneous injection, continuous 10 d, rat model of cardiac hypertrophy. 2 day modeling treated with different concentrations of butanol extract Polygonum or NS, 14 d continuous , after the last administration fasting 12 h, weighed, decapitated after anesthesia blood serum LDH activity, myocardial Na +-K +-ATPase, Ca2 + - ATPase, CK and LDH activity. Results The serum LDH activity increased myocardial Na +-K +-ATPase, Ca2 + - ATPase, CK and LDH activity decreased compared with model group, Polygonum butanol extract treatment serum LDH activity decreased myocardial Na +-K +-ATPase , Ca2 + ATPase, CK and LDH activity increased. Conclusion Polygonum butanol extract can enhance the Na +-K +-ATPase, Ca2 + - ATPase activity from myocardial hypertrophy. [Keywords:] butanol extract Polygonum, myocardial hypertrophy, sodium and potassium ATP enzyme, calcium enzyme ATP Polygonum with heat, Anticonvulsant, the rationale for the wet and other effects. Polygonum extract by 95% ethanol, then washed with petroleum ether, ethyl acetate, n-butanol, n-butanol part of its derived butyl Polygonum alcohol extract (Polygonum Bistorla L. n-Butyl Alcohol Extract, PBNA, the main component of clove and rutin, catechins and Mururin A [1]. there experiments showed that the extract of Polygonum anti-arrhythmia [2] analgesia [3], central inhibition [4], myocardial ischemia protection [5] and so on. cardiac hypertrophy is increased myocardial cell size and protein content increases as the main feature of the compensatory response is stimulation of a variety of cardiovascular fact