Poorly differentiated prostate cancer serum PSA of possible mechanisms of change.doc

 PAGE \* MERGEFORMAT 18 Poorly differentiated prostate cancer serum PSA of possible mechanisms of change Study: South Xun Yi, Wang Mingzhu, He Dalin, Xing Junping, Fan Jinhai, Duyue Feng, Li Xiang [Abstract] Objective To investigate patients with poorly differentiated prostate cancer, PSA levels increase or decrease the possible mechanism of changes to improve the accuracy of such changes in the correct understanding and treatment of these diseases for clinical reference. Method analysis of 20 patients in this group of poorly differentiated prostate cancer and 2 cases of undifferentiated adenocarcinoma of serum PSA level changes, combined with domestic and foreign literature on PSA changes may occur because of the mechanism. Results of 20 cases of poorly differentiated adenocarcinoma in 4 cases only slightly higher than normal PSA accounted for 20% (5.7 ~ 27.21 ng / ml, an average of 16.79 ng / ml) more than 16 cases high, accounting for as much as 80% of the PSA (gt; 100 ~ 5 000 ng / ml, an average of 888.16 ng / ml) than the average .2 cases of more than 200 times the normal undifferentiated adenocarcinoma, and 1 slightly higher PSA 4.8 ng / ml, the other 1 case ofgt; 100 ng / ml average of 52.4 ng / ml, still 12 times higher than normal. Conclusion reported low differentiation of prostate cancer and their reduced ability to secrete PSA prostate cancer cells in the blood barrier breakdown, serum PSA is considered to be poorly differentiated prostate cancer cases in the decrease or increase of the main causes and mechanisms. But the data show that addition of low in this group elevated serum PSA prostate cancer differentiation or low (and highly differentiated adenocarcinoma compared) by many factors such as different stages of cancer progression, cancer heterogeneity and individual differences in patients, and other factors. In short a single prostate cancer blood barrier breakdown in the secretion of PSA or prostate cancer low capacity, it can not expl