PPAR agonists on A induced nerve injury in Progress.docVIP

 PAGE \* MERGEFORMAT 14 PPAR agonists on A induced nerve injury in Progress [Keywords:] PPAR agonists A nerve injury Peroxisome proliferator-activated receptors (Peroxisome Proliferator-Activated Receptor, PPAR target gene expression to regulate nuclear receptor transcription factor family members [1]. Has been reported as PPAR in fat, kidney, and embryonic development fundamental role, PPAR knockout mice are embryonic lethal. In that PPAR in macrophages also expressed later, PPAR agonists have been proposed on the immune and inflammatory responses with the adjustment, can inhibit the release of various inflammatory mediators. PPAR agonists by reducing -amyloid protein (Amyloid-, A deposition and to reduce the expression of pro-inflammatory cytokines, inhibition of nerve damage caused by A [2,3]. 1 PPAR Overview 1.1 PPAR structure PPAR has 9 exons to form four functional domains: amino-terminal domain, MAPK phosphorylation of this domain can be certain serine residues, phosphorylation can inhibit the activity of PPAR, DNA binding domain. PPAR by This domain and the corresponding response element DNA binding to regulate gene transcription, domain transcriptional regulation of activity, many nuclear factors binding to this domain can affect the activity of PPAR, ligand binding domain, the domain of From hormone signal transduction to the transcriptional activation play a key role in the process [4,5]. 1.2 PPAR ligands and antagonists PPAR ligands, including natural ligands and synthetic ligands categories. Natural ligand are: essential fatty acids and their metabolites. Prostaglandin derivative, a 15d-PGJ2, PGD2, PGA, etc., and other ligands and so on. Synthesis with body, including TZDs drugs thiazolidinediones (TZD): troglitazone (TGZ), rosiglitazone, pioglitazone, Central, and pioglitazone [6], carboxylic acid agonists: non-steroidal anti-inflammatory drugs ( indomethacin, sulindac, ibuprofen), etc. [7], @ - replace-A-phenyl-propioni