Progesterone capsule on serum sex hormone levels and polycystic ovary ovarian P450arom expression.doc

 PAGE \* MERGEFORMAT 15 Progesterone capsule on serum sex hormone levels and polycystic ovary ovarian P450arom expression [Abstract] Objective To observe the progesterone capsule of polycystic ovary (PCO) morphology of rat ovary, serum sex hormone levels and ovarian P450arom expression to explore the role of PCO in rats may be targets and mechanisms. Methods insulin combined with others chorionic gonadotropin (HCG) Preparation modeling PCO model rats were randomly divided into control group, model group, progesterone capsule group, the metformin group, 30 times the adult dose administration. progesterone capsules were given 3.0 g / (kg · d), metformin group was 0.75 g / (kg · d), the control group and model group were fed an equal volume of distilled water and 1 mL/100 g body weight. light microscopy ovary, follicular development situation radioimmunoassay Serum sex hormone levels, detected by immunohistochemistry the expression of ovarian tissue P450arom. Results progesterone capsules could PCO rats increased ovarian granulosa cell layer, foam layer of thin film cells, serum testosterone, luteinizing hormone, decreased insulin levels , follicle stimulating hormone and estradiol levels and ovarian granulosa cells increased the expression of P450arom. Conclusion progesterone capsules can be direct or indirect role in influencing the expression of ovarian tissue P450arom to adjust the PCO on reproductive endocrine play role in promoting follicle development and ovulation. [Keywords:] polycystic ovary syndrome, progesterone capsules, sex hormones, P450arom, rat Abstract: Objective To observe the effects of Zhuyunjiaonang on morphological change of the ovary, serous hormone and the expression of P450arom in PCO model rats. To explore its target and mechanism in treating PCO model rats. Methods Using INS and HCG to establish PCO model. The PCO rat models were devided into 4 groups randomly, which included control group, model group, Zhuyunjiaonang group and