Progress in the pharmacological effects of saffron.docVIP

 PAGE \* MERGEFORMAT 16 Progress in the pharmacological effects of saffron [Keywords:] saffron; pharmacology Safflower (Carthamus tinctorius L.) to Compositae annual herb, mainly in Henan, Zhejiang, Sichuan, Yunnan and Xinjiang. Ancient medical books and “The lt;Compendium of Materia Medicagt;gt; documented in both, is the blood circulation of the one of traditional Chinese medicine. The main chemical composition is yellow (saffloryellow, SY), HSYA A (hydroxysafflor yellow A, HSYA), safflower glycosides, safflower safflower quinone glycoside, etc. and the new, national scholars promoting blood circulation and other pharmacological effects of its material basis for a number of experimental studies, the paper since 2000, mainly on the pharmacological effects of saffron to make a review for the majority of researchers. An anticoagulant Platelet-activating factor PAF (platelet avtivating factor is the strongest activator of platelet aggregation in blood circulation plays an important disease mediators, water-soluble components in safflower yellow composition containing mainly ketones Charles, Ming Jin, Wen-Mei Chen et al study found that safflower yellow pigment inhibited PAF induced platelet aggregation and platelet intracellular free Ca2 + concentration increases [1], yellow (SYP, safflower yellow pigment deuterium labeled in vitro with platelet PAF receptor binding the impact of the experimental results show that in vitro, Yellow PAF receptor can inhibit the binding, and showed significant dose-effect relationship. Xia Yu, who found that leaf [2] HSYA A (HSYA) 1 ~ 4mg · kg-1 intravenous injection of thrombosis and AA (arachidonic acid induced platelet aggregation was significantly inhibited, reducing the release of AA may lead to hypoperfusion of cerebral ischemia, platelet microthrombi formation and cerebral circulation disorders. SYP also significantly lower in patients with idiopathic edema whole blood viscosity (high shear, low shear, plasma vi