Qingyi positive side of pancreatic cancer CFPAC1 xenografts in nude mice and serum levels of interleukin 6 interleukin 8 and tumor necrosis factorin.doc

 PAGE \* MERGEFORMAT 22 Qingyi positive side of pancreatic cancer CFPAC1 xenografts in nude mice and serum levels of interleukin 6 interleukin 8 and tumor necrosis factorin Of: Ouyang Huaqiang, Liu Luming, Chen Zhen, Luo Jianmin, on Yeltsin [Abstract] Objective: To observe the Qingyi product (Qingyi Huaji, QYHJ) side of human pancreatic cancer CFPAC 1 cell line xenografts in nude mice and serum inhibitory effect of interleukin-6 (interleukin 6, IL 6, interleukin 8 (interleukin 8, IL 8 and tumor necrosis factor-@ (tumor necrosis factor @, TNF @ expression. Methods: 40 nude mice subcutaneously transplanted the right forelimb axillary block of the establishment of tumor pancreatic tumor model. successful model The nude mice were randomly divided into model group, capecitabine group, low dose (36 g / kg) Qingyi product side group and high dose (72 g / kg) Qingyi product side group, n = 10 were used with Arabic gum citrate buffer, capecitabine Qingyi suspension and fed liquid product side. 5 weeks after orbital blood, enzyme-linked immunosorbent assay of serum IL 6, IL 8 and TNF @ content, nude mice were killed off the spine, peeling the tumor, check the quality, measuring tumor size, inhibitory rate was calculated. Results: The low dose group Qingyi square plot of nude mice CFPAC 1 decline in the quality Compared with model group, the difference was statistically significant (P lt;0.05). high and low dose group Qingyi nude square plot of serum levels of IL 6 and TNF @ was significantly lower than model group (P lt;0.01, and low doses of the Qing positive side of pancreatic capecitabine group and the serum levels of IL 8 lower than the model group (P lt;0.05). Correlation analysis showed that the quality of nude mice and serum IL 6, IL 8 and TNF @ level was a linear positive correlation (P lt;0.01). Conclusion: Conventional dose side of the plot Qingyi pancreatic cancer xenograft model in nude mice significantly inhibitory effect, and its mechanism may be asso