Rat model of acute cardiac allograft rejection in the performance of ultrasound.docVIP

 PAGE \* MERGEFORMAT 14 Rat model of acute cardiac allograft rejection in the performance of ultrasound Of: Wu Wei, Zhuo Lisha, Ding, He Yun, Hua Hin [Abstract] Objective To evaluate the acute rejection of rat cardiac transplantation model ultrasonography. Methods cardiac isograft and allograft model. To 14 MHz frequency probe the first postoperative day of cardiac allograft line 1,3,6 echocardiography, in the short axis view of left ventricular papillary muscles of left ventricular end diastolic dimension (LVDd, left ventricular wall thickness (LVT, wall thickening (LVTR and left ventricular ejection fraction (LVEF, and compare the isograft and the difference between allograft. Results isograft group no acute cardiac allograft rejection, allograft group after 3 days of heart transplant pathological grade level for the I ~ II, 6 days after transplantation, the pathological grade to III ~ IV level. isograft group, 1,3,6 days after operation to observe the dynamic ultrasound showed no significant change (Pgt; 0.05. its time between the two groups, LVDd was no significant difference (Pgt; 0.05, patients after 6 days, allograft group LVEF was significantly lower than isograft group (P lt;0.05, after the first 3,6 days, the allograft group was significantly higher than that of LVT isograft group (P lt;0.01, while the LVTR is significantly lower (P lt;0.01. Conclusion High frequency ultrasound can dynamically display the anatomy of heart transplantation in rats, changes in structure and function, to determine different degrees of acute rejection, LVT and LVTR can be used as a sensitive indicator of its evaluation. [Keywords:] heart transplantation, acute rejection, ultrasonography Abstract: Objective To evaluate the ultrasonography of acute rejection of heart transplantation in rat model. Methods Models of isotransplantation and allotransplantation in rats were established with Brown Norway rats as donors and Lewis rats as acceptors. Ultrasonography was p