Rat model of acute pyelonephritis on the Establishment and Observation.docVIP

 PAGE \* MERGEFORMAT 12 Rat model of acute pyelonephritis on the Establishment and Observation Of: Zhou Dong, Sun Wei, He Weiming, GAO Kun, Tao Xing, Karen Chen [Abstract] Objective pyelonephritis with people making similar animal model for clinical treatment of acute and chronic urinary tract infections and lay a experimental basis. Methods to rats with unilateral ureteral “semi-ligation” and also injection of E. coli to the bladder methods result in pathological changes of acute pyelonephritis, and apply nourishing customs capsules, three gold pieces and other intervention observation. Results of acute pyelonephritis in dose group, western medicine, Chinese and Western medicine group was weight gain in rats, administration good body of rats after drug treatment is effective. Conclusions rat model of acute pyelonephritis in the growth state, body mass index, kidney weight and renal pathological changes in terms of coefficients are similar to human disease pyelonephritis, successful model. [Keywords:] acute pyelonephritis, Kidney clearance capsule, rat Abstract: Objective To made the animal model which is similar to the human pyelonephritis to strengthen the experimental basis for the therapy of acute urologic infectious disease. Method Using the method of semi-ligation of the ureter on single lateral and the injection of Enterobacter into the bladder to get pathologic transformation. Simultaneously, giving the different preparation of Zishen-tongguan Capsule, Sanjin Pills to intervene the models. Result Zishentongguan capsule middle dosage, western medicine treatment team had get obviously effect on rat body weight increasing, the drug treatment were validity . Conclusion The rat model with the acute nephropyelitis is similar to the character in the break of human, which manifest on the appearance, mental condition, body weight coefficient, kidney weight coefficient and pathologic change of the kidney. Succeed in the model establishment. Keywo