Recipe on the kidney with unilateral ureteral obstruction on renal tissue expression of ED1 and the impact of NF-κB function.doc

 PAGE \* MERGEFORMAT 11 Recipe on the kidney with unilateral ureteral obstruction on renal tissue expression of ED1 and the impact of NF-κB function Of: Shi-Zhu Sun Wei Wang Jiming, Karen Chen, Hsuan-Hsuan Chu Lai Rensheng [Abstract] Objective To investigate the basis for living kidney serum Patent Law prescriptions on UUO (UUO rat model) in rat renal interstitial ED1 and NF-κB expression. Prepared rat model of unilateral ureteral obstruction randomly divided into sham operation group, model group, kidney Recipe group, kidney Recipe high dose group, benazepril group. observed after 21 days of renal interstitial ED1 and NF- κB expression. Results of Chinese medicine group than in model group, the renal interstitial ED1 and the expression of NF-κB were significantly different; benazepril group the expression of ED1 compared with the model group significantly. Conclusion benefits Recipe for renal interstitial fibrosis, and NF-κB in the expression of ED1 has good control effects, benazepril group UUO rats can inhibit the expression of renal interstitial ED1. [Keywords:] Kidney Recipe; unilateral ureteral obstruction (UUO); ED1 (macrophages); NF-κB (nuclear factor) [Abstract] Objective To identify whether Yishen Huoxue Qingli recipe plays an important role in vivo in preventing the development of tubulointerstitial fibrosis after unilateral ureteral obstruction in rats.Methods To establish the UUO model in vivo, the rats were randomly divided into five groups: sham opermion group, model group, the yishen huoxue qingli Chinese medicine group, the high dosage Chinese medicine group and the benazepril group.After 21 days the expression of ED1 and NF-κB was detected by immunohistochemistry. Result The expression level of ED1 and NF- κB in the UUO group were significantly increased.The ED1 level of the groups with drugs was less than the UUO group, the role in the Chinese medicine group (P lt;0.01), the high dose Chinese medicine group, and the benazepril gro