Recipe on the Qi rat model of myocardial infarction in the mobilization of bone marrow stem cells and left ventricular remodeling.doc

 PAGE \* MERGEFORMAT 12 Recipe on the Qi rat model of myocardial infarction in the mobilization of bone marrow stem cells and left ventricular remodeling Of: Yang has, Lu Shu, Yu Gong less, Sun Huiru [Abstract] Objective To compare the observed Recipe Qi and granulocyte colony stimulating factor (G-CSF) on rat model of myocardial infarction mobilization of bone marrow stem cells and left ventricular remodeling. Anterior descending coronary artery ligation method of modeling to detect mouse model modeling day, 5 days and 10 days of peripheral blood stem cells in circulation was calculated 8 weeks of treatment left ventricular mass index, wall thinning rate and the inflation index. Results of peripheral blood stem cells in medicine group in the making mode after 5 d was significantly higher (P lt;0.001), 5 d after withdrawal, still higher than the western medicine group (P lt;0.001). Medicines heart weight index decreased (P lt;0.001), wall thinning rate increased swelling index decreased significantly (respectively P lt;0.05, P lt;0.001). Conclusion Recipe Qi has a good mobilization of bone marrow stem cells, the G-CSF mobilization of more durable, have in the fight against ventricular remodeling better than G- CSF trend. [Keywords:] myocardial infarction, bone marrow stem cells, left ventricular remodeling, Qi Recipe Abstract: Objective To contrast and observe the bone marrow stem mobilization induced by Yiqi Wenyang Huoxuefang and G-CSF, and the influence to left ventricle reconstruction. Methods Model rat was made by ligate LAD, quantity of circulation stem cells (CSC) at the first , fifth and tenth day was detected. After be treated 8 weeks, the heart index, the expansion index and the thinning ratio were calculated. Results The quantity of CSC of Chinese herbs group increased at the fifth day (P lt;0.001). After withdrawal medicine 5 days, it is higher than medicine group (P lt;0.001). The heart index and the EI decreased remarkable (respectivel