Reperfusion arrhythmias in traditional Chinese medicine research.docVIP

 PAGE \* MERGEFORMAT 6 Reperfusion arrhythmias in traditional Chinese medicine research Reperfusion arrhythmias (reperfusion arrhythmias, RA) refers to the ischemic myocardium in some or all of the resumption of blood flow occurred in the course of arrhythmia. Acute myocardial infarction (AMI) infarct vessel recanalization after thrombolytic therapy, myocardial perfusion and oxygen supply to regain enable the transmural AMI case fatality rate declined. However, myocardial reperfusion active oxygen free radicals (O-, HO-, and H202) with fulminant elected to regain myocardial oxygen supply, the additional damage by oxygen free radicals, can myocardial microvascular injury or cell death, myocardial stunning, cardiac electrical instability, resulting in RA, disease caused by a complex of [1,2]. RA is the AMI reperfusion therapy, one of the major complications, but also sudden death in patients with ischemia-reperfusion one of the reasons. In order to effectively prevent the occurrence of RA, the occurrence of RA at home and abroad in recent years, the mechanism and drug prevention and treatment carried out extensive research, including traditional Chinese medicine treatment of myocardial ischemia and reperfusion arrhythmia research made great progress. Are summarized below. A mechanism of reperfusion arrhythmias Research Status Control RA must understand its mechanism, its occurrence mechanism is very complex, the main points are the following: Some scholars believe that: cytoplasmic calcium overload and reperfusion arrhythmias there was a close relationship. Yukihiko Yoshida [3], etc. with the adenylate cyclase inhibitor, dipyridamole (Dipyridamole) experiment, reached the termination of dipyridamole to protect and reperfusion arrhythmias, so cAMP-induced triggered activity may lead to the occurrence of reperfusion arrhythmias. Some scholars in the study of anti-arrhythmic mechanism of ischemic preconditioning, they found such a protective mechanism of ischem