Research of natural killer cells.docVIP

 PAGE \* MERGEFORMAT 18 Research of natural killer cells [Abstract] natural killer cells (referred to as NK cells) is a human anti-tumor and anti-infection immunity, clearing alien cells in the first natural line of defense, since the 20th century was discovered 70 years, has been the research focus of scholars at home and abroad, the paper reviews NK cells present subsets, receptors, immune response mechanisms and clinical application of the status quo. [Keywords:] natural killer cell; the status quo; review literature Beginners in the 20th century, the age of 70 T cells to target cells and found the specific anti-rat or a control group of mice spleen cells as spleen cells from mice immunized with tumor destruction as certain tumor cells, and then in normal peripheral blood lymphocytes can be found in sources of natural killer cells in some cancers. Since the killing function of these cells does not require pre-immune sensitization occurs, so named for the natural killer cells (NK cells). scholars have made NK cells were then The main body of the bearer of Innate Immunity and NK cells not only found on cancer cells, viruses, intracellular parasites and aging variant cell also has a strong scavenging ability of NK cells fully confirmed the important role in the human body. This present on NK cells subsets, NK cell receptors, immune response mechanisms and clinical application of research status are reviewed. 1 NK cell subsets Human peripheral blood NK cells accounted for about 5% of total lymphocytes 15%, the expression of CD56 surface antigen, did not express the surface antigen CD3. According to the different expression of CD56 antigen, NK cells can be divided into two subgroups, 90% to 95% NK cells CD56dimCD16bright cells, only a small part of the NK cells CD56brightCD16dim/neg cells. CD56brightCD16 NK cells secrete cytokines such as IFN as the main feature, CD56dimCD16 + NK cells to killing the main function. CD56dim and CD56bright resting c