Rosuvastatin in elderly patients with inflammatory effect of inhibiting lipid.docVIP

 PAGE \* MERGEFORMAT 10 Rosuvastatin in elderly patients with inflammatory effect of inhibiting lipid [Abstract] Objective To compare rosuvastatin and atorvastatin in elderly patients with lipid inhibiting inflammation. Methods 75 cases of elderly patients with dyslipidemia were randomly divided into A, B, C three groups, A group was given atropine atorvastatin (10 mg / d), B group was given rosuvastatin (5 mg / d), C group received rosuvastatin (10 mg / d), three groups were taking 12 w. Before treatment, treatment for 4 end w, 12 w measured fasting blood were collected at the end TC, LDL C, TG, HDL C, IL 6, IL 10, TNF @. Results three groups before treatment was no difference in the indices (Pgt; 0.05); 4 w at the end, TC, LDL C, TG were lower, HDL C were increased (P lt;0.01); 12 w late, no changes in blood lipids (Pgt; 0.05). 4 w at the end, A, B group TC, LDL C compared no difference (Pgt; 0.05), C group TC, LDL C compared with A, B groups decreased (P lt;0.01). 4 w at the end, three groups of IL 6, TNF @ lower, IL 10 increased (P lt;0.01); 12 w end of the continuous changes in inflammatory factors (P lt;0.01). In addition to 12 w TNF @ the end of C group was slightly lower than the B group, but did not see the changes in inflammatory factors in the three groups are different (Pgt; 0.05). CONCLUSION Alto Atorvastatin and rosuvastatin are lipid suppression inflammation, and inhibiting inflammation is independent of the outside of Lipid Metabolism. rosuvastatin 5 mg / d and atorvastatin 10 mg / d lipid lowering effect is similar to , rosuvastatin 10 mg / d lipid effects than atorvastatin 10 mg / d. rosuvastatin and atorvastatin inhibit inflammation roughly equal. [Keywords:] rosuvastatin; old; interleukin-6; Interleukin 10; tumor necrosis factor @ In addition to lipid lowering statin effects, can also inhibit inflammatory cytokines, reduce the risk of cardiovascular events (1). Study of rosuvastatin on dyslipidemia in patients with low-densit